论文成果
Propargylamine Synthesis by Copper-Catalyzed Oxidative Coupling of Alkynes and Tertiary Amine N-Oxides
- 点击次数：
- 论文类型：期刊论文
- 发表时间：2011-08-19
- 发表刊物：JOURNAL OF ORGANIC CHEMISTRY
- 收录刊物：SCIE、EI、PubMed
- 文献类型：J
- 卷号：76
- 期号：16
- 页面范围：6901-6905
- ISSN号：0022-3263
- 摘要：An efficient method for synthesizing N,N-di-methylpropargylamines is described. The synthesis exploited the Cu(II)-catalyzed oxidative alkynylation reaction of tri-methylamine N-oxides with alkynes in the absence of external oxidant. Both aromatic and aliphatic allcynes were utilized to achieve the corresponding products in moderate to excellent yields. The reaction conditions tolerated ester, hydroxy, and aldehyde groups.
