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Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

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Indexed by:期刊论文

Date of Publication:2015-07-07

Journal:CHEMICAL SOCIETY REVIEWS

Included Journals:SCIE、PubMed、ESI高被引论文、Scopus

Volume:44

Issue:13

Page Number:4337-4366

ISSN No.:0306-0012

Abstract:Transition metals (d-blocks) are recognized as playing critical roles in biology, and they most often act as cofactors in diverse enzymes; however, improper regulation of transition metal stores is also connected to serious disorders. Therefore, the monitoring and imaging of transition metals are significant for biological research as well as clinical diagnosis. In this article, efforts have been made to review the chemical sensors that have been developed for the detection of the first-row d-block metals (except Cu and Zn): Cr, Mn, Fe, Co, and Ni. We focus on the development of fluorescent sensors (fall into three classes: "turn-off'', "turn-on'', and ratiometric), colorimetric sensors, and responsive MRI contrast agents for these transition metals (242 references). Future work will be likely to fill in the blanks: (1) sensors for Sc, Ti, and V; (2) MRI sensors for Cr, Mn, Co, Ni; (3) ratiometric fluorescent sensors for Cr6+, Mn2+, and Ni2+, explore new ways of sensing Fe3+ or Cr3+ without the proton interference, as well as extend applications of MRI sensors to living systems.

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