Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2011-02-21

Journal: ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals: Scopus、PubMed、EI、SCIE

Volume: 9

Issue: 4

Page Number: 980-983

ISSN: 1477-0520

Abstract: A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations.