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Indexed by:期刊论文

Date of Publication:2011-02-21

Journal:ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals:SCIE、EI、PubMed、Scopus

Volume:9

Issue:4

Page Number:980-983

ISSN No.:1477-0520

Abstract:A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations.