郭慧敏

个人信息Personal Information

副教授

硕士生导师

性别:女

毕业院校:Regensburg大学

学位:博士

所在单位:化学学院

学科:分析化学

电子邮箱:guohm@dlut.edu.cn

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Aggregation-Induced Emission (AIE) Fluorophore Exhibits a Highly Ratiometric Fluorescent Response to Zn2+ in vitro and in Human Liver Cancer Cells

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论文类型:期刊论文

发表时间:2017-09-21

发表刊物:CHEMISTRY-A EUROPEAN JOURNAL

收录刊物:Scopus、SCIE、EI、PubMed

卷号:23

期号:53

页面范围:13067-13075

ISSN号:0947-6539

关键字:aggregation-induced emission; bioimaging; fluorophores; sensors; zinc

摘要:Two novel organic fluorophores, containing bis-naphthylamide and quinoline motifs, have been designed and synthesized. One of the fluorophores contains an isobutylene unit and exhibits a significant aggregation-induced emission (AIE) and a remarkable highly selective ratiometric fluorescence response towards Zn2+ in solution as well as in human liver cancer cells. The AIE behavior of this fluorophore was fully verified by fluorescence and UV/Vis spectroscopy, quantum yield calculations, and single-crystal X-ray diffraction, which revealed an intricate crystal packing system. Conversely, a fluorophore that lacks the isobutylene moiety did not exhibit any significant fluorescent properties as a result of its more flexible molecular structure that presumably allows free intramolecular rotational processes to occur.