伍会健

个人信息Personal Information

教授

博士生导师

硕士生导师

任职 : 教授

性别:男

毕业院校:九州大学理学部

学位:博士

所在单位:生物工程学院

学科:生物化学与分子生物学. 细胞生物学. 生药学

办公地点:生物楼603

联系方式:邮编:116024 大连市高新区凌工路2号 大连理工大学生物楼603 电话:0411-84706105

电子邮箱:wuhj@dlut.edu.cn

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The role of AIB1 in breast cancer

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论文类型:期刊论文

发表时间:2012-10-01

发表刊物:ONCOLOGY LETTERS

收录刊物:SCIE、PubMed

卷号:4

期号:4

页面范围:588-594

ISSN号:1792-1074

关键字:breast cancer; AIB1; nuclear receptors; hormone-dependent signaling

摘要:Amplified in breast cancer 1 (AIB1) is a member of the p160 steroid receptor coactivator family that mediates the transcriptional activities of nuclear receptors including estrogen receptor (ER) and progesterone receptor (PR), as well as certain other transcription factors, including E2F1 and p53. AIB1 is widely implicated in nuclear receptor-mediated diseases, particularly malignant diseases, including breast, prostate, gastric and pancreatic cancers. AIB1 was initially implicated in hormone-dependent breast cancer, where increasing levels of AIB1 mRNA and protein were detected in some of these specimens and the overexpression of AIB1 in mice led to an increased incidence of tumors. More recent studies revealed that AIB1 also affects the growth of hormone-independent breast cancer via signaling pathways such as those of E2F1, IGF-I, EGF and PI3K/Akt/mTOR. The pleiotropic effect of AIB1 and the roles it plays in both normal development and cancer have presented a great challenge to formulating an effective therapeutic strategy for breast cancer. In this review, we highlight the significant progress made with the recent findings and present an overview of the current understanding of the influence of AIB1 on breast cancer via hormone-dependent and -independent signaling pathways.