Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2011-08-17

Journal: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Included Journals: PubMed、EI、SCIE、Scopus

Volume: 133

Issue: 32

Page Number: 12402-12405

ISSN: 0002-7863

Abstract: Metal-organic polyhedra represent a unique class of functional molecular containers that display interesting molecular recognition properties and fascinating reactivity reminiscent of the natural enzymes. By incorporating a triphenylamine moiety as a bright blue emitter, a robust cerium-based tetrahedron was developed as a luminescent detector of nitronyl nitroxide (PTIO), a specific spin-labeling nitric oxide (NO) trapper. The tetrahedron encapsulates molecules of NO and PTIO within the cavity to prompt the spin-trapping reaction and transforms the normal EPR responses into a more sensitively luminescent signaling system with the limit of detection improved to 5 nM. Twelve-fold amide groups are also functionalized within the tetrahedron to modify the hydrophilic/lipophilic environment, ensuring the successful application of biological imaging in living cells.