点击次数：

论文类型：期刊论文

发表时间：2017-12-21

发表刊物：CATALYSIS SCIENCE & TECHNOLOGY

收录刊物：SCIE、EI

卷号：7

期号：4

页面范围：5872-5881

ISSN号：2044-4753

摘要：The peroxy and trifluoromethyl groups play important roles in pharmacy, but it is challenging to introduce both of them selectively into the target molecules in a homogeneous catalytic system. In the presence of the easily available metal-organic framework Cu-3(BTC)(2) (also well known as HKUST-1), novel peroxy-trifluoromethylation of styrenes was achieved in a heterogeneous mode. The rigid 3D framework of Cu-3(BTC)(2) is necessary to maintain the structural integrity of the binuclear paddle-wheel Cu(II) catalytic center for the effective electrophilic activation of Togni's reagent and TBHP with a low loading amount of the catalyst and its easy re-use, and the bowl bottom-like confined environment around the copper node is vital for the discrimination of reaction sites with different steric demands. Compared with homogeneous copper salts, the heterogeneous Cu-3(BTC)(2) showed superior catalytic activity and intrinsic shape- and regio-selectivity for this reaction. The peroxy moieties of the products could be easily converted to carbonyl or hydroxyl groups for further applications.