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论文类型：期刊论文

发表时间：2019-02-04

发表刊物：Small (Weinheim an der Bergstrasse, Germany)

收录刊物：PubMed、Scopus

页面范围：e1804770

ISSN号：1613-6829

关键字：asymmetric catalysis,chiral,confined space,metal-organic cages,metal-organic frameworks

摘要：The effective synthesis of chiral compounds in a highly enantioselective manner is obviously attractive. Inspired by the enzymatic reactions that occur in pocket-like cavities with high efficiency and specificity, chemists are seeking to construct catalysts that mimic this key feature of enzymes. Recent progress in supramolecular coordination chemistry has shown that metal-organic cages (MOCs) and metal-organic frameworks (MOFs) with chiral confined cavities/pores may offer a novel platform for achieving asymmetric catalysis with high enantioselectivity. The inherent chiral confined microenvironment is considered to be analogous to the binding pocket of enzymes, and this pocket promotes enantioselective transformations. This work focuses on the recent advances in MOCs and MOFs with chiral confined spaces for asymmetric catalysis, and each section is separated into two parts based on how the chirality is achieved in these metal-organic architectures. A special emphasis is placed on discussing the relationship between the enantioselectivity and the confined spaces of the chiral functional MOCs and MOFs rather than catalytic chemistry. Finally, current challenges and perspectives are discussed. This work is anticipated to offer researchers insights into the design of sophisticated chiral confined space-based metal-organic architectures for asymmetric catalysis with high enantioselectivity.© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.