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论文类型：期刊论文

发表时间：2012-09-30

发表刊物：TETRAHEDRON

收录刊物：SCIE、Scopus

卷号：68

期号：39

页面范围：8371-8375

ISSN号：0040-4020

关键字：Probe; NO; Copper complex; Fluorescence imaging

摘要：A novel copper(II) complex CuQNE with a naphthalimide-containing ligand was synthesized as a fluorescent sensor of nitric oxide (NO). It featured eightfold fluorescent enhancement toward NO from a dark-background with the detection limit of NO about 1 nM in aqueous solution. The fluorescence response of the CuQNE was specific for NO, the presence of other reactive oxygen species (ROS) and reactive nitrogen species (RNS) did not interfere with the detection of NO in aqueous solution. LC-MS and IR spectra of the reaction mixture both demonstrated that the fluorescence enhancement was possibly attributed to an NO-induced nitrosation of the amino group. Confocal fluorescence images of MCF-7 cells suggested that CuQNE could be applied for monitoring intracellular NO. (C) 2012 Published by Elsevier Ltd.