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个人信息Personal Information
副教授
硕士生导师
性别：女
毕业院校：协和医科大学
学位：博士
所在单位：生物工程学院
学科：生物化学与分子生物学. 生物化工. 生物医学工程
办公地点：生物楼302
联系方式：13478968672 0411-84706316
电子邮箱：xu-li@dlut.edu.cn
Water-soluble adsorbent beta-cyclodextrin-grafted polyethyleneimine for removing bilirubin from plasma
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论文类型：期刊论文
发表时间：2012-10-01
发表刊物：TRANSFUSION AND APHERESIS SCIENCE
收录刊物：SCIE、PubMed、Scopus
卷号：47
期号：2
页面范围：159-165
ISSN号：1473-0502
关键字：Bilirubin; beta-Cyclodextrin; Polyethyleneimine; Water-soluble adsorbent
摘要：A water-soluble adsorbent was developed for removing bilirubin from the plasma of hyper-bilirubinemia patient. The adsorbent was synthesized by grafting beta-cyclodextrin (beta-CD) to branched polyethyleneimine (PEI) matrix. The resulting beta-CD-PEI polymer had an average molecular weight of 163.7 kD, and it contained 56.3 beta-CD functional groups. In beta-CD-PEI-spiked dialysis, 35.8% of plasma bilirubin was removed, which was higher than that removed by the same concentration of bovine serum albumin. beta-CD-PEI also removed aromatic amino acids and bile acids. The results indicated that beta-CD-PEI could be an effective adsorbent for blood purification application aiming at the removal of toxins. (C) 2012 Published by Elsevier Ltd.