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Indexed by:期刊论文

Date of Publication:2017-10-01

Journal:SENSORS AND ACTUATORS B-CHEMICAL

Included Journals:SCIE、EI

Volume:250

Page Number:267-273

ISSN No.:0925-4005

Key Words:Biomimetic fluorescent probe; Gallium detection; Biological tissues; Clinical examination; Environmental monitoring

Abstract:The application of Ga-based compounds in medical and industrial fields could induce accumulation of gallium in the human body, and further exert certain Ga-toxic effect on health. So it is very important for gallium detection in biological aspects and different environments. Fluorescent analysis owning various merits surpass other analytic methods and received great attention recently. In this work, a biomimetic crab-like fluorescent probe denoted as NL was designed and successfully synthesized, which can selectively recognize Ga3+ from other metal ions in acetate buffer/DMSO (v/v=1/1, pH=5. 2), and the limit of detection was 12.89 nM. Moreover, this probe can detect Ga3+ in complex environments, such as human serum and urine, pork, rabbit kidney and rabbit liver, and even in simulated pollution water. Besides, the proposed method can provide portable test for Ga3+ and reach a detection limit to 1.2 mg/Kg by naked eye under ultraviolet irradiation, which is lower than the toxic concentration (4 mg/Kg) of Ga3+ permitted in organs. The results indicated that NL can be further applied in clinical examination and environmental detection, and the biomimetic designing can provide reference to the development of other fluorescent sensors. (C) 2017 Elsevier B.V. All rights reserved.