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Indexed by:期刊论文

Date of Publication:2007-08-01

Journal:BIOORGANIC & MEDICINAL CHEMISTRY

Included Journals:SCIE、PubMed

Volume:15

Issue:15

Page Number:5114-5121

ISSN No.:0968-0896

Key Words:aryl/heteroaryl-imidazonaphthalimides; '4-1' pentacyclic DNA-intercalating agents

Abstract:A novel series of '4-1' pentacyclic naphthalimides, where the chromophore consists of a naphthalimide moiety, fused to an imidazole ring containing an unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In general, the new derivatives showed an improved cytotoxic activity over amonafide. DNA binding experiments supported that this class of compounds behaves as effective DNA-intercalating agents. (c) 2007 Elsevier Ltd. All rights reserved.