Release Time:2019-11-01  Hits:

Indexed by: Journal Article

Date of Publication: 2005-07-01

Journal: CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

Included Journals: CSCD、ISTIC、SCIE

Volume: 21

Issue: 4

Page Number: 480-483

ISSN: 1005-9040

Key Words: photocleaver; 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile; singlet oxygen; cytotoxicity

Abstract: The photocleavage abilities of a novel family of compounds, 8-oxo-8H-acenaphtho[1, 2-b] pyrrole-9-carbonitrile and its derivatives(compounds 1-5) were evaluated with MI3 mp18 single strand circular DNA. Only compound 1 with a diethylamine group could bind to DNA via electrostatic attraction and intercalation. At a concentration of 50 mu mol/L, it could generate singlet oxygen to cleave circular DNA into linear DNA under the irradiation of long wavelength light(lambda > 400 nm). The antitumor ability of compound 1 was also evaluated in vitro, and its IC50 on HeLa cells was as low as 6.8 mu mol/L.