Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2014-05-01

Journal: CARBON

Included Journals: Scopus、EI、SCIE

Volume: 71

Page Number: 190-195

ISSN: 0008-6223

Abstract: The fluorescence of propidium iodide (PI) can be effectively quenched with the addition of graphene oxide (GO) in aqueous solution, due to the formation of a physical adsorption material named GO-PI. A fluorescence enhancement of approximately 80 times can be observed after addition of a certain amount of DNA/RNA into the above-mentioned solution. Meanwhile, it is found that the GO-PI can enter into the nuclei and stain the DNA/RNA of living human breast cancer cells MCF-7, while PI alone cannot cross the cellular membrane in the control experiment, demonstrating GO can be employed to be an efficient PI delivery nanomaterial for live cell staining. (C) 2014 Elsevier Ltd. All rights reserved.