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盐酸特拉唑嗪降解产物的结构鉴定

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Indexed by:期刊论文

Date of Publication:2016-05-08

Journal:色谱

Included Journals:Scopus、PKU、ISTIC、CSCD

Volume:34

Issue:5

Page Number:490-497

ISSN No.:1000-8713

Key Words:高效液相色谱-高分辨多级质谱;结构鉴定;降解产物;盐酸特拉唑嗪

Abstract:盐酸特拉唑嗪是一种新型选择性α1-肾上腺能受体拮抗剂,用于治疗高血压和良性前列腺增生。采用高效液相色谱-高分辨多级质谱(HPLC-HRMSn)联用法对强氧化条件下盐酸特拉唑嗪原料药的降解产物进行了详细的解析和结构确证。共检测到15种降解产物,其中7种与文献报道的有关物质相同,另外8种为新检测到的降解产物,其主要降解途径为酰胺键水解、羟基化、羰基化及3种途径组合的次级降解途径。

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