NAME

董悦生

Paper Publications

Production of polyketides with anthelmintic activity by the fungus Talaromyces wortmannii using one strain-many compounds (OSMAC) method
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    期刊论文

  • First Author:

    Liu, Wen-Cai

  • Correspondence Author:

    Dong, YS (reprint author), Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Liaoning, Peoples R China.

  • Co-author:

    Yang, Fan,Zhang, Ran,Shi, Xuan,Lu, Xin-Hua,Luan, Yu-Shi,Xiu, Zhi-Long,Dong, Yue-Sheng

  • Date of Publication:

    2016-12-01

  • Journal:

    PHYTOCHEMISTRY LETTERS

  • Included Journals:

    SCIE、Scopus

  • Document Type:

    J

  • Volume:

    18

  • Page Number:

    157-161

  • ISSN No.:

    1874-3900

  • Key Words:

    Talaromyces wortmannii; Polyketides; OSMAC; Absolute configuration; Anthelmintic activity; NADH-fumarate reductase inhibitor

  • Abstract:

    Three new polyketides, wortmannilactones I1-I3, were purified from Talaromyces wortmannii using the One Strain Many Compounds (OSMAC) strategy. The polyketides' structures were established using IR, 1D and 2D NMR, and HRESIMS analyses and the absolute configurations were identified by comparison of experimental and calculated ECDs. These polyketides exhibit selective inhibitory activity against NADH-fumarate reductase. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.

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