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Indexed by:期刊论文

Date of Publication:2009-03-01

Journal:HELVETICA CHIMICA ACTA

Included Journals:SCIE、EI、Scopus

Volume:92

Issue:3

Page Number:567-574

ISSN No.:0018-019X

Abstract:Wortmannilactones E-H (1-4), four new cathepsin B inhibitors, were produced and isolated from the culture of the soil filamentous fungus Talaromyces wortmannii, Their structures and relative configurations were elucidated on the basis of 1D- and 2D-NMR techniques, three of them (1, 2, and 4) posses an oxabicyclo[2.2.1]heptane moiety. Compounds 1-4 showed inhibitory activities against cathepsin B with IC(50) values of 4.3, 6.5, 13.0, and 6.0 mu M, respectively.