Release Time:2019-03-10  Hits:

Indexed by: Journal Article

Date of Publication: 2009-03-01

Journal: HELVETICA CHIMICA ACTA

Included Journals: Scopus、EI、SCIE

Volume: 92

Issue: 3

Page Number: 567-574

ISSN: 0018-019X

Abstract: Wortmannilactones E-H (1-4), four new cathepsin B inhibitors, were produced and isolated from the culture of the soil filamentous fungus Talaromyces wortmannii, Their structures and relative configurations were elucidated on the basis of 1D- and 2D-NMR techniques, three of them (1, 2, and 4) posses an oxabicyclo[2.2.1]heptane moiety. Compounds 1-4 showed inhibitory activities against cathepsin B with IC(50) values of 4.3, 6.5, 13.0, and 6.0 mu M, respectively.