Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2014-03-17

Journal: SYNLETT

Included Journals: Scopus、SCIE

Volume: 25

Issue: 5

Page Number: 724-728

ISSN: 0936-5214

Key Words: reductions; aldol reactions; lactones; domino reactions; copper; catalysis

Abstract: The first copper-catalyzed reductive aldol addition/lactonization domino reactions of alpha,beta-unsaturated dicarboxylate esters with ketones were achieved in high yields. The method, which involves easily available reagents, a flexible combination of reactants, and mild conditions, provides a simple route to functionalized lactones bearing an ester group.