点击次数：
论文类型：期刊论文
发表时间：2013-01-01
发表刊物：CRYSTENGCOMM
收录刊物：SCIE、Scopus
卷号：15
期号：23
页面范围：4711-4720
ISSN号：1466-8033
摘要：Six new hybrid species based on amino acid functionalized gamma-octamolybdates, [(H2O)(3)M](2)[Mo8O26(pro)2]center dot 2H(2)O (M = Cu 1, Zn 2, Co 3), [(H2O)(8)(lys)(2)Cu-3][Mo8O27]center dot 12H(2)O (4), and [(H2O)(6)M][Mo8O26(lysH)(2)]center dot 4H(2)O (M = Zn 5, Co 6) (pro = proline; lys, lysH = lysine), have been synthesized and characterized by elemental analysis, IR and UV-vis spectroscopy, TG analysis, powder X-ray diffraction and single crystal X-ray diffraction. Compounds 1-3 are isostructural, consisting of proline functionalized gamma-octamolybdates linked by metal cations (M = Cu2+, Zn2+ and Co2+) to form a 2D framework with 4-connected topology. The proline functionalized gamma-octamolybdates [Mo8O26(pro)(2)](4-) consist of two gamma-type [Mo8O26](4-) anions covalently bridged by two proline molecules via the carboxyl oxygen atoms. When a lysine molecule was used instead of the proline ligand, compounds 4-6 with different structures were obtained. In 4, the gamma-octamolybdates are firstly linked to a 1D chain via sharing oxygen atoms, and then adjacent chains are joined together by trinuclear {Cu-3(lys)(2)} coordination fragments to yield a 2D network as a rare (3,6)-connected net with the Schlafli symbol (3.6(2))(3(4).4(2).6(2).7(4).8(3)). When Zn2+ and Co2+ cations were added to replace Cu2+, isostructural 5 and 6 were obtained, respectively, and they are constructed from lysine functionalized gamma-octamolybdates [Mo8O26(lysH)(2)](2-) and free metal-H2O coordination cations. The activities of 1-6 against two human tumor cell lines (human breast cancer MCF-7 and human liver hepatocellular cells HepG2) were investigated in vitro. Cu- and Zn-directed amino acid functionalized POMs exhibit higher activities than Co-directed POMs and the parent amino acid functionalized octamolybdates ([Mo8O26(pro)(2)](4-) and [Mo8O26(lysH)(2)](2-)), which opens up new ways of developing novel drugs based on amino acid functionalized molybdate clusters.