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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：兰州大学
学位：博士
所在单位：化工学院
学科：有机化学. 药物化学. 精细化工
办公地点：西部校区化工实验楼G-413
联系方式：0411-84986190 15942819406
电子邮箱：bmwang@dlut.edu.cn
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Asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides with alpha,beta-ynones: a straightforward approach to spirooxindoles incorporating 2,5-dihydropyrroles and pyrroles
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论文类型：期刊论文
发表时间：2017-04-30
发表刊物：CHEMICAL COMMUNICATIONS
收录刊物：SCIE、PubMed
卷号：53
期号：34
页面范围：4714-4717
ISSN号：1359-7345
摘要：An organocatalytic asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides and alpha,beta-ynones has been developed. This reaction afforded spiro[dihydropyrrole-2,3'-oxindole] products in high chemical yields with excellent stereoselectivities (up to 99% yields, 420 : 1 dr and > 99% ee). Notably, a series of important spiro[pyrrole-oxindole] derivatives were readily obtained via oxidation of the cycloadducts, thus extending the diversity of the products.