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论文类型：期刊论文

发表时间：2018-09-14

发表刊物：ORGANIC & BIOMOLECULAR CHEMISTRY

收录刊物：SCIE

卷号：16

期号：34

页面范围：6275-6283

ISSN号：1477-0520

摘要：An iodine-mediated alkenylation of pyrazolones with simple alkenes under an air atmosphere has been developed. By this protocol, the pharmaceutically relevant pyrazolone scaffold was directly adorned with a readily transformable olefinic functional group through a cross-dehydrogenative coupling process in moderate to excellent yields. The coupling products could be facilely manipulated by, for example, the Heck reaction and hydrogenation treatment, thus enriching the pyrazolone derivatives. Based on the observation of the reaction intermediate and mechanistical experiments, two possible reaction pathways were proposed.