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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：兰州大学
学位：博士
所在单位：化工学院
学科：有机化学. 药物化学. 精细化工
办公地点：西部校区化工实验楼G-413
联系方式：0411-84986190 15942819406
电子邮箱：bmwang@dlut.edu.cn
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Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides
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论文类型：期刊论文
发表时间：2016-07-01
发表刊物：ORGANIC LETTERS
收录刊物：SCIE、PubMed
卷号：18
期号：13
页面范围：3082-3085
ISSN号：1523-7060
摘要：A facile method has been developed for the synthesis of chiral piperazines through Ir-catalyzed hydrogenation of pyrazines activated by alkyl halides, giving a wide range of chiral piperazines including 3-substituted as well as 2,3- and 3,5-disubstituted ones with up to 96% ee. The high enantioselectivity, easy scalability, and concise drug synthesis demonstrate the practical utility.