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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：兰州大学
学位：博士
所在单位：化工学院
学科：有机化学. 药物化学. 精细化工
办公地点：西部校区化工实验楼G-413
联系方式：0411-84986190 15942819406
电子邮箱：bmwang@dlut.edu.cn
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Iridium-Catalyzed Selective Hydrogenation of 3-Hydroxypyridinium Salts: A Facile Synthesis of Piperidin-3-ones
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论文类型：期刊论文
发表时间：2015-04-03
发表刊物：ORGANIC LETTERS
收录刊物：SCIE、PubMed、Scopus
卷号：17
期号：7
页面范围：1640-1643
ISSN号：1523-7060
摘要：The selective hydrogenation of 3-hydroxypyridinium salts has been achieved using a homogeneous iridium catalyst, providing a direct access to 2- and 4-substituted piperidin-3-one derivatives with high yields, which are important organic synthetic intermediates and the prevalent structural motifs in pharmaceutical agents. Mild reaction conditions, high chemoselectivity, and easy scalability make this reaction highly practical for the synthesis of piperidin-3-ones.