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抗仔猪腹泻重组肠毒素暨菌毛复合多价疫苗制备及预防效果的研究

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Indexed by:会议论文

Date of Publication:2012-10-09

Page Number:1

Key Words:复合多价疫苗;肠毒素;ETEC;初生仔猪;菌毛;毒力因子;抗原蛋白;血清型;仔猪发病率;仔猪腹泻率;

Abstract:仔猪腹泻(Diarrhea)是由某些特定血清型的产肠毒素大肠杆菌(Enterotoxingenic E.coli,ETEC)引起的,是导致初生仔猪死亡的主要病因之一。目前防治ETEC性仔猪腹泻最有效的方法是疫苗。本研究从导致腹泻的两个毒力因子——肠毒素和菌毛着手,利用前期工作完成的可表达重组三价肠毒素(STa-LTB-STb,SLS)的大肠杆菌制备重组SLS抗原蛋白,同

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