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个人信息Personal Information
副教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：生物工程学院
学科：微生物学. 生物工程与技术
办公地点：西部校区生物工程学院405
联系方式：xiaoyuli@dlut.edu.cn 0411-84709800
电子邮箱：xiaoyuli@dlut.edu.cn
Isolation and characterization of a bacteriophage and its potential to disrupt multi-drug resistant Pseudomonas aeruginosa biofilms
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论文类型：期刊论文
发表时间：2019-01-23
发表刊物：Microbial pathogenesis
收录刊物：PubMed、Scopus
卷号：128
页面范围：329-336
ISSN号：1096-1208
关键字：Bacteriophage,Biofilm,Pseudomonas aeruginosa
摘要：A lytic Pseudomonas aeruginosa bacteriophage, vB_PaeM_LS1, was isolated and characterized herein. To examine the eligibility of bacteriophage vB_PaeM_LS1 as a therapeutic bacteriophage, we analysed its genome and compared it to similar bacteriophages. Genome of bacteriophage vB_PaeM_LS1 consisted of a linear, double-stranded DNA molecule 66,095 bp in length and with 55.7% G + C content. Neighbor-joining analysis of the large subunit terminase showed that bacteriophage vB_PaeM_LS1 had similarity to the Pbunavirus genus. The potential of the lytic bacteriophage to disrupt Pseudomonas aeruginosa biofilms was assessed by scanning electron microscopy and bacterial counts. This study revealed that the bacteriophage vB_PaeM_LS1 with its lytic effect showed a high potential impact on the inhibition of the growth of Pseudomonas aeruginosa biofilm formation.Copyright © 2019 Elsevier Ltd. All rights reserved.
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