点击次数：

论文类型：期刊论文

发表时间：2009-03-01

发表刊物：FREE RADICAL RESEARCH

收录刊物：SCIE、PubMed

卷号：43

期号：3

页面范围：224-233

ISSN号：1071-5762

关键字：Methylmercury; apoptosis; oxidative stress; pyrroloquinoline quinone; neuroprotection; antioxidant

摘要：Pyrroloquinoline quinone (PQQ) is a novel redox cofactor and also exists in various foods. In vivo as well as in vitro experimental studies have shown that PQQ functions as an essential nutrient or antioxidant. Methylmercury (MeHg), as a highly toxic environmental pollutant, could elicit central nervous system (CNS) damage. Considering the antioxidant properties of PQQ, this study was aimed to evaluate the effect of PQQ on MeHg-induced neurotoxicity in the PC12 cells. The results showed that, after pre-treatment of PC12 cells with PQQ prior to MeHg exposure, the MeHg-induced cytotoxicity was significantly attenuated and then the percentage of apoptotic cells and the arrest of S-phase in cell cycle were correspondingly reduced. Moreover, PQQ significantly decreased the production of ROS, suppressed the lipid peroxidation and increased the antioxidant enzyme activities in PC12 cells exposed to MeHg. These observations highlighted the potential of PQQ in offering protection against MeHg-induced neuronal toxicity.