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全氟辛烷磺酸(PFOS)对神经突触可塑性的影响及机理研究

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Indexed by:会议论文

Date of Publication:2016-07-01

Page Number:1-1

Key Words:全氟辛烷磺酸;发育神经毒性;毒性机制;钙稳态

Abstract:　　本文研究目的是阐明全氟辛烷磺酸(PFOS)的发育神经毒性机理。利用交叉哺育模型模拟出生前/后暴露，通过长时程增强(LTP)模型评估PFOS对神经突触可塑性的影响，并从神经元细胞发育、凋亡、钙信号转导通路调控等角度探讨相关机理。出生前暴露导致胚胎期和出生早期仔鼠血清和脑组织中PFOS的累积水平较高。

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