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Indexed by:期刊论文

Date of Publication:2012-01-01

Journal:JOURNAL OF ANIMAL AND VETERINARY ADVANCES

Included Journals:SCIE、Scopus

Volume:11

Issue:18

Page Number:3355-3364

ISSN No.:1680-5593

Key Words:Volatile organic compounds; hippocampus; Morris water maze; oxidative damage; NMDA receptor; learning and memory

Abstract:Volatile Organic Compounds (VOCs) susceptibility is triggered by VOCs present both indoors and outdoors. It has become an important public health concern in both domestic and occupational settings. In the present study, memory and learning capacity, grip strength of mice after exposed to VOCs were investigated. Meanwhile, N-Methyl-D-Aspartate (NMDA) receptor subunit 1, 2A and 2B expressions in hippocampus and oxidative damage levels in brain were analyzed. Results showed no significant changes in grip strength but mice following exposure to high dose VOCs took significantly longer swimming time to reach the platform and made more errors in comparison to the control. The RT-PCR analysis also revealed NR1, NR2A, NR2B decreased in hippocampus. Moreover, VOCs exposure induced oxidative stress in. brain. The findings indicate that short-term VOCs inhalation didn't induce damage on physique and motor function of mice but negatively affected learning and memory capacity by decreasing expression of the NMDA receptor through the direct effects on the nervous system. Oxidative damage in brain might be implicated in VOCs-induced neurotoxicity.