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论文类型：期刊论文

发表时间：2019-06-01

发表刊物：INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES

收录刊物：SCIE、EI

卷号：91

页面范围：72-76

ISSN号：0143-7496

关键字：Hot-melt pressure-sensitive adhesives; SIS-g-PB copolymers; In vitro drug release; Adhesive performance

摘要：SIS-g-PB copolymers were successfully synthesized by grafting living polybutadiene (PB) lithium macroanions onto epoxidized SIS copolymers. Their molecular structures and thermal properties were characterized by TGA, H-1-NMR and DSC, respectively. SIS, epoxidized SIS (ESIS) and SIS-g-PB copolymers were melt-blended with tackifiers to develop hot-melt pressure-sensitive adhesives (HMPSAs), respectively (named of H-SIS, H-ESIS and H-SIS-g-PB). Their adhesive performances were measured in terms of 180 degrees peel strength and holding power. A modified Franz type horizontal diffusion cell was used to carry out In vitro drug release experiments, in which geniposides were chosen as hydrophilic model drugs. The results showed that H-SIS-g-PB has two times as high a 180 degrees peel strength as H-SIS. Meanwhile H-SIS-g-PB has a slightly lower drug cumulative release rate than H-ESIS. It is indicated that the PB branches not only could impart good adhesive performance to H-SIS-g-PB via improving the compatibility between the epoxidized main chains and tackifier resins but also provide release channels to hydrophilic drugs by retaining most of the epoxide groups in the SIS-g-PB copolymers.