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Indexed by:期刊论文

Date of Publication:2013-01-01

Journal:PURE AND APPLIED CHEMISTRY

Included Journals:SCIE、EI

Volume:85

Issue:4

Page Number:843-849

ISSN No.:0033-4545

Key Words:asymmetric hydrogenation; dibenzothiazepines; heterocyclic chemistry; iodine; iridium

Abstract:Highly enantioselective hydrogenation of substituted dibenzo[b,f][1,4]thiazepines was achieved with up to 96 % ee (enantiomeric excess) using [Ir(COD)Cl](2)/(R)-SynPhos complex as catalyst in the presence of iodine. This method provides an efficient access to optically active 11-substituted-10,11-dihydrodibenzo[b,f][1,4]thiazepines.