Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2013-01-01

Journal: PURE AND APPLIED CHEMISTRY

Included Journals: EI、SCIE

Volume: 85

Issue: 4

Page Number: 843-849

ISSN: 0033-4545

Key Words: asymmetric hydrogenation; dibenzothiazepines; heterocyclic chemistry; iodine; iridium

Abstract: Highly enantioselective hydrogenation of substituted dibenzo[b,f][1,4]thiazepines was achieved with up to 96 % ee (enantiomeric excess) using [Ir(COD)Cl](2)/(R)-SynPhos complex as catalyst in the presence of iodine. This method provides an efficient access to optically active 11-substituted-10,11-dihydrodibenzo[b,f][1,4]thiazepines.