Iridium-catalyzed asymmetric hydrogenation of dibenzo[b,f][1,4]thiazepines
点击次数：
论文类型：期刊论文
发表时间：2013-01-01
发表刊物：PURE AND APPLIED CHEMISTRY
收录刊物：EI、SCIE
卷号：85
期号：4
页面范围：843-849
ISSN号：0033-4545
关键字：asymmetric hydrogenation; dibenzothiazepines; heterocyclic chemistry; iodine; iridium
摘要：Highly enantioselective hydrogenation of substituted dibenzo[b,f][1,4]thiazepines was achieved with up to 96 % ee (enantiomeric excess) using [Ir(COD)Cl](2)/(R)-SynPhos complex as catalyst in the presence of iodine. This method provides an efficient access to optically active 11-substituted-10,11-dihydrodibenzo[b,f][1,4]thiazepines.