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论文类型：会议论文

发表时间：2016-10-12

收录刊物：EI、CPCI-S、Scopus

卷号：10027

关键字：Sensing; optical fiber; LSPR; nano particle

摘要：We present a localized surface plasmon resonance fiber optic biosensor based on an intensity interrogation mechanism. A layer of gold nano sphere is deposited on a fiber optic sensor probe which works as the sensing element and is immobilized on the sidewall of an unclad optical fiber via two different immobilization methods (amino silane method and layer by layer self-assembly method). Different self-assembly layers were also respectively investigated by using layer by layer self-assembly method to explore the optimum layer number. Experimental results reveal that PDDA/PSS/PAH layer self-assembly method provides the best LSPR response. We obtain a refractive index sensitivity as 6.57RIU(-1) in a RI range of 1.3266 similar to 1.3730. We also conduct real-time and label free monitoring of Ribonuclease B/Con A biomolecular interaction by using this sensor prototype and demonstrate it can perform qualitative and quantitative detection in real-time biomolecular sensing.