Indexed by: 会议论文

Date of Publication: 2017-01-01

Included Journals: CPCI-S

Document Type: A

Volume: 2017-December

Page Number: 1-6

Key Words: UPDRS; speech signals; framework of ensemble feature selection; personalized predictive model

Abstract: The unified Parkinson's disease rating scale (UPDRS) is the most widely employed scale for tracking Parkinson's disease (PD) symptom progression. However, conventional way to achieve UPDRS, mainly based on the physical examinations of clinic patients performed by the trained medical staffs, involves the disadvantages of inconvenience and high medical expense. Hence, in this study, we try to explore some risk factors and accurately predict the UPDRS for PD, using the speech signals of PD patients published on UCI machine-learning archive. More specifically, inspired by the idea of ensemble learning, we firstly construct a framework of ensemble feature selection (EFS) to select a suitable subset of features among numerous speech signals. Subsequently, a personalized predictive model, trained by adopting information from similar patients, is developed to be customized for an individual PD patient. Finally, we employ the personalized predictive model to predict UPDRS score combined with various classical regression algorithms. Compared to conventional models, our study has a potential to capture more relevant risk factors and produces more accurate UPDRS score for individual patient. Experimental results on real-world dataset from UCI machine-learning archive show that our personalized predictive model gets a promising performance.