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Isoquinolone Synthesis through SNAr Reaction of 2-Halobenzonitriles with Ketones Followed by Cyclization

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Indexed by:期刊论文

Date of Publication:2015-04-17

Journal:JOURNAL OF ORGANIC CHEMISTRY

Included Journals:SCIE、EI、PubMed、Scopus

Volume:80

Issue:8

Page Number:3998-4002

ISSN No.:0022-3263

Abstract:An efficient method for the synthesis of isoquinolones through base (KOBu)-Bu-t-promoted SNAr reaction of 2-halobenzonitriles with ketones followed by Lewis acid Cu(OAc)(2)-catalyzed cyclization is described. Isoquinolone derivatives were obtained in satisfactory to good yields.

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