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Efficient palladium-catalyzed cyanation of aryl/heteroaryl bromides with K-4[Fe(CN)(6)] in t-BuOH-H2O using tris(2-morpholinophenyl)phosphine as a ligand

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Indexed by:期刊论文

Date of Publication:2013-11-21

Journal:RSC ADVANCES

Included Journals:SCIE、EI、Scopus

Volume:3

Issue:43

Page Number:20379-20384

ISSN No.:2046-2069

Abstract:A practical method for the synthesis of various aryl/heteroaryl nitriles using non-toxic K-4[Fe(CN)(6)] as the cyanide source is described. The cyanation of aryl/heteroaryl bromides with K-4[ Fe(CN)(6)] proceeded smoothly in the presence of a Pd/tris(2-morpholinophenyl)phosphine (L5) catalyst under mild conditions. The corresponding aryl/heteroaryl nitriles were produced in good to excellent yields.

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