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论文类型： 期刊论文

发表时间： 2017-02-17

发表刊物： JOURNAL OF ORGANIC CHEMISTRY

收录刊物： SCIE、EI、PubMed

卷号： 82

期号： 4

页面范围： 2288-2293

ISSN号： 0022-3263

摘要： A convenient and efficient method for the synthesis of 5H-dibenzo[c,e]azepine-5,7(6H)-diones from simple and readily available benzamides is described in this work. The palladium-catalyzed homocoupling of benzamides occurred via ortho-selective double C-H bond activation using the simplest amide CONH2 as a directing group. The subsequent intramolecular condensation reaction proceeded smoothly to produce 5H-dibenzo[c,e]azepine-5,7(6H)-diones in satisfactory to excellent yields in one pot.