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论文类型： 期刊论文

发表时间： 2018-11-16

发表刊物： ORGANIC LETTERS

收录刊物： PubMed、SCIE、Scopus

卷号： 20

期号： 22

页面范围： 7095-7099

ISSN号： 1523-7060

摘要： A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.