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发布时间：2019-03-12

论文类型：期刊论文

发表时间：2018-11-16

发表刊物：ORGANIC LETTERS

收录刊物：Scopus、SCIE、PubMed

卷号：20

期号：22

页面范围：7095-7099

ISSN号：1523-7060

摘要：A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.