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论文类型： 期刊论文

发表时间： 2016-05-01

发表刊物： ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录刊物： SCIE

卷号： 5

期号： 5

页面范围： 699-704

ISSN号： 2193-5807

关键字： 1-naphthols; aryl halides; copper catalysis; ortho-haloacetophenones; SNAr reactions

摘要： An efficient method was developed for the synthesis of 1-naphthols through NaOtBu-promoted SNAr reaction of ortho-haloacetophenones followed by Lewis acid CuI-catalyzed intramolecular condensation and isomerization. 1-Naphthol derivatives were obtained in satisfactory yields from aryl bromide and aryl iodide substrates.