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Indexed by:会议论文

Date of Publication:2014-06-18

Included Journals:EI、CPCI-S、Scopus

Page Number:724-729

Abstract:A dynamic model is proposed to quantify the relationship among extracellular agonist ATP, intracellular Ca2+ dynamics and NFAT activation in stem cells. Based upon the dynamic model, the intracellular Ca2+ and NFAT dynamics in stem cells induced by different kinds of ATP stimuli are investigated through numerical simulation studies. The simulation results not only reproduce intracellular Ca2+ and NFAT dynamics stimulated by constant concentration of ATP, which were observed in the previous experimental studies in the literature, but also predict some new dynamic behaviors of intracellular Ca2+ and NFAT in stem cells in response to time-varying ATP stimulation. The proposed dynamic model provides not only more insights into the ATP-induced intracellular Ca2+ and NFAT dynamics but also a quantitative way to regulate the intracellular Ca2+ and NFAT dynamics by controlling the extracellular agonist ATP stimulation in stem cells.