Release Time:2019-03-11  Hits:

Indexed by: Conference Paper

Date of Publication: 2014-06-18

Included Journals: Scopus、CPCI-S、EI

Page Number: 724-729

Abstract: A dynamic model is proposed to quantify the relationship among extracellular agonist ATP, intracellular Ca2+ dynamics and NFAT activation in stem cells. Based upon the dynamic model, the intracellular Ca2+ and NFAT dynamics in stem cells induced by different kinds of ATP stimuli are investigated through numerical simulation studies. The simulation results not only reproduce intracellular Ca2+ and NFAT dynamics stimulated by constant concentration of ATP, which were observed in the previous experimental studies in the literature, but also predict some new dynamic behaviors of intracellular Ca2+ and NFAT in stem cells in response to time-varying ATP stimulation. The proposed dynamic model provides not only more insights into the ATP-induced intracellular Ca2+ and NFAT dynamics but also a quantitative way to regulate the intracellular Ca2+ and NFAT dynamics by controlling the extracellular agonist ATP stimulation in stem cells.