Release Time:2019-03-11  Hits:

Indexed by: Journal Article

Date of Publication: 2017-10-01

Journal: APPLIED MATHEMATICS AND MECHANICS-ENGLISH EDITION

Included Journals: EI、SCIE、Scopus

Volume: 38

Issue: 10

Page Number: 1481-1496

ISSN: 0253-4827

Key Words: shallow Y-shaped microfluidic channel; dynamic biochemical signal; non-reversing pulsatile flow; nonlinear amplitude-frequency modulation; Taylor-Aris dispersion

Abstract: The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.