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Date of Publication:2022-10-10
Journal:中国医疗设备
Volume:33
Issue:4
Page Number:22-28
ISSN No.:1674-1633
Abstract:Objective To examine the validity of an upper-arm cuff-based pulse wave device (PASESA AVE-1500) on assessing central arterial stiffness based on oscillometric waves, and analyze the related influential factors. Methods A computational model of the cardiovascular system coupled with an upper-arm oscillometric cuff was constructed and applied to simulate the measurement process of the pulse wave device. With the model, a theoretical study for assessing central arterial stiffness based on the characteristics of cuff oscillometric wave was performed, followed by a series of numerical experiments aimed to quantify the sensitivity of the assessment to various cardiovascular parameters. Furthermore, the validity of the pulse wave device was examined by clinical experiments. Results The computational model-based theoretical study revealed that the ratio of the second valley to the first peak (|V2|/|P1|) on the time-differentiated cuff wave correlated positively with the stiffness of central arteries. Subsequent numerical experiments showed that |V2|/|P1| increased with the impairment of cardiac systolic function, but was relatively less influenced by the total peripheral vascular resistance and the stiffness of the brachial artery. The clinical study demonstrated that the measured pulse velocity index (AVI) differed significantly between the patient group with cardiovascular diseases (n=68) and the healthy subject group (n=170) (P<0.0001), which was consistent with the inter-group difference observed for brachial-ankle pulse wave velocity (baPWV) (P<0.0001). In addition, AVI was found to correlate significantly with both baPWV (r=0.656, P<0.0001) and age (r=0.525, P<0.0001). Conclusion The mechanical property of central arteries can be obtained by analyzing the oscillometric wave of an upper-arm cuff, which makes it possible to noninvasively and rapidly assess central arterial stiffness.
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