Hits:

Indexed by:期刊论文

Date of Publication:2014-06-21

Journal:JOURNAL OF THEORETICAL BIOLOGY

Included Journals:SCIE、PubMed、Scopus

Volume:351

Page Number:58-66

ISSN No.:0022-5193

Key Words:Human spermatozoa; Calcium signaling; Progesterone; Mathematical modeling

Abstract:Calcium ion is a secondary messenger of mammalian spermatozoa. The dynamic change of its concentration plays a vital role in the process of sperm motility, capacitation, acrosome and fertilization. Progesterone released by the cumulus cells, as a potent stimulator of fertilization, can activate the calcium channels on the plasma membrane, which in turn triggers the dynamic change of intracellular calcium concentration. In this paper, a mathematical model of calcium dynamic response in mammalian spermatozoa induced by progesterone is proposed and numerical simulation of the dynamic model is conducted. The results show that the dynamic response of calcium concentration predicted by the model is in accordance with experimental evidence. The proposed dynamic model can be used to explain the phenomena observed in the experiments and predict new phenomena to be revealed by experimental investigations, which will provide the basis to quantitatively investigate the fluid mechanics and biochemistry for the sperm motility induced by progesterone. (C) 2014 Elsevier Ltd. All rights reserved.