Hits:

Indexed by:期刊论文

Date of Publication:2013-07-01

Journal:MATHEMATICAL BIOSCIENCES

Included Journals:SCIE、EI、PubMed、Scopus

Volume:244

Issue:1

Page Number:47-57

ISSN No.:0025-5564

Key Words:Intracellular calcium ion concentration; Electrical stimulation; Calcium ion channels; Fibroblasts; Dynamic model

Abstract:Regulation of intracellular calcium ion concentration ([Ca2+](in)) in fibroblasts induced by exogenous electrical stimulation could be applied to control gene expressions selectively which in turn modulate the function of the fibroblasts. Regarding the mechanism for electric-field-induced Ca2+ influx via voltage-gated Ca2+ channels and/or stretch-activated cation channels in the fibroblasts, a dynamic mathematical model is proposed to quantify the [Ca2+](in) dynamics in response to direct current or alternating current electric fields. Simulation results demonstrate that the changes in [Ca2+](in) predicted by our dynamic model are consistent with the experimental data in the literature. The proposed dynamic model could provide not only more insights into the electric-field-induced intracellular Ca2+ response but also a quantitative way to regulate the [Ca2+](in) dynamics by controlling the external electrical stimulation. (c) 2013 Elsevier Inc. All rights reserved.