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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：光电工程与仪器科学学院院长、党委副书记
其他任职：辽宁省先进光电子技术重点实验室副主任，大连市新型功能材料与光电子器件重点实验室主任，中国超材料学会理事，中国机械工程学会极端制造分委员会委员，国际先进材料学会会士，Microsystems&Nanoengineering、chemosensors等期刊副编辑
性别：男
毕业院校：布里斯托尔大学
学位：博士
所在单位：光电工程与仪器科学学院
学科：光学工程. 电磁场与微波技术. 光学. 测试计量技术及仪器. 精密仪器及机械
办公地点：研教楼706
联系方式：0411-84706156
电子邮箱：caotun1806@dlut.edu.cn
Transmission of dynamic biochemical signals in the shallow microfluidic channel: nonlinear modulation of the pulsatile flow
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论文类型：期刊论文
发表时间：2018-08-01
发表刊物：MICROFLUIDICS AND NANOFLUIDICS
收录刊物：SCIE
卷号：22
期号：8
ISSN号：1613-4982
关键字：Dynamic biochemical signals; Microfluidics; Transmission characteristics; Nonlinear modulation; Low-pass filtering
摘要：A controlled quantitative loading of dynamic biochemical signals on cells in vitro is essential for cell dynamic analysis. Microfluidics provides the potential for reproducing and controlling spatio-temporal biochemical signals through the various microfluidic channels. Herein we investigate the transmission characteristics of dynamic biochemical signals in pulsatile flows by analytically solving the convection-diffusion equation for the time-dependent Taylor-Aris dispersion with perturbation method. We prove that the transmission of dynamic biochemical signals in pulsatile flows is subject to the two correlate effects: low-pass filtering and nonlinear amplitude-frequency modulation. These two effects are systematically characterized and the influence factors are studied, including the biochemical signal frequency, the pulsatile flow frequency, the transmission distance and the average pulsatile flow rate. We concluded that the balance of multiple factors should be taken into account for better loading biochemical signals on cells cultured in the microfluidic channel.