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论文类型：期刊论文

发表时间：2011-09-15

发表刊物：CHEMICAL ENGINEERING SCIENCE

收录刊物：Scopus、SCIE、EI

卷号：66

期号：18

页面范围：4101-4110

ISSN号：0009-2509

关键字：Aerobic fermentation; Biomass biosynthesis; Bioprocess stability; Corynebacterium glutamicum; Optimisation; Periodic solutions

摘要：This work concerns the modelling of the Corynebacterium glutamicum biosynthesis. At the beginning, the impulsive growth model of C. glutamicum under glutamate inhibition is established. According to this model, the analysis of the bioprocess stability is presented. Then, new objective functions are proposed and optimisation of C. glutamicum growth is presented. The results of the optimisation indicate that, although the growth of C glutamicum is an aerobic process, the maximum of biomass productivity occurs under controlled penetration into the area of aerobic fermentation. Analytical results presented in this work are validated by numerical simulations. (C) 2011 Elsevier Ltd. All rights reserved.