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Picomolar detection of carcinoembryonic antigen in whole blood using microfluidics and surface-enhanced Raman spectroscopy

Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-03-01

Journal: ELECTROPHORESIS

Included Journals: Scopus、PubMed、SCIE

Volume: 37

Issue: 5-6

Page Number: 786-789

ISSN: 0173-0835

Key Words: Carcinoembryonic antigen; Microfluidics; SERS; Magnetic nanoparticles

Abstract: Carcinoembryonic antigen (CEA) is a wide-spectrum biomarker. Clinically, we generally use serum sample to detect CEA, which needs to be centrifuged to pretreat the raw blood sample. In this study, we realized direct CEA detection in raw blood samples exploiting microfluidics. The LOD was as low as 10(-12) M.

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