点击次数：

论文类型：期刊论文

发表时间：2015-07-01

发表刊物：Analytical chemistry insights

收录刊物：Scopus、PubMed

卷号：10

期号：1

页面范围：39-45

关键字：drug screening,microenvironment,organ-on-a-chip,tissue engineering

摘要：Direct detection and analysis of biomolecules and cells in physiological microenvironment is urgently needed for fast evaluation of biology and pharmacy. The past several years have witnessed remarkable development opportunities in vitro organs and tissues models with multiple functions based on microfluidic devices, termed as "organ-on-a-chip". Briefly speaking, it is a promising technology in rebuilding physiological functions of tissues and organs, featuring mammalian cell co-culture and artificial microenvironment created by microchannel networks. In this review, we summarized the advances in studies of heart-, vessel-, liver-, neuron-, kidney- and Multi-organs-on-a-chip, and discussed some noteworthy potential on-chip detection schemes.