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论文类型：期刊论文

发表时间：2016-01-01

发表刊物：RSC ADVANCES

收录刊物：SCIE

卷号：6

期号：42

页面范围：35248-35256

ISSN号：2046-2069

摘要：We developed a biomimetic microfluidic model to reproduce hallmark events of tumor-induced angiogenesis. The angiogenic capabilities of salivary gland adenoid cystic carcinoma (ACC) cells and oral squamous cell carcinoma (SCC) cells were assessed in this model. The traditional nude mouse xenograft model was used to investigate the physiological similarity of the microfluidic model to animal models, and the results showed that the angiogenic potential of ACC and SCC cells assessed by the microfluidic model was in agreement with the results obtained from the nude mouse model. The microfluidic model was subsequently used to evaluate the effect of antiangiogenic drugs on ACC- and SCC-induced angiogenesis. The antiangiogenic effect of anti-VEGF was further compared between the microfluidic and nude mouse models, and showed that it effectively inhibited tumor-induced angiogenesis in both the microfluidic model and the nude mouse model. Thus, tumor-induced angiogenesis reproduced in the microfluidic model may expand the capabilities of cell culture models, providing a low-cost, timesaving, and rapid alternative to animal models.