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高级工程师
硕士生导师
性别:女
毕业院校:大连理工大学
学位:博士
所在单位:环境学院
学科:环境工程
办公地点:知渊楼A315
联系方式:0411-84707965 email:hexin@dlut.edu.cn
电子邮箱:hexin@dlut.edu.cn
Distribution of perfluoroalkyl compounds in rats: Indication for using hair as bioindicator of exposure
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论文类型:期刊论文
发表时间:2015-11-01
发表刊物:JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
收录刊物:SCIE、PubMed、Scopus
卷号:25
期号:6
页面范围:632-638
ISSN号:1559-0631
关键字:perfluoroalkyl acids; hair; serum; tissue; urine; feces
摘要:Hair analysis is potentially advantageous in exposure assessment of perfluoroalkyl acids (PFAAs) as a non-invasive method, combined with the ability to reflect long-term exposure. The present study aims to assess the feasibility of using hair as an indicator of PFAA exposure. Adult male and female rats were subchronically exposed to selected PFAAs, including perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorooctanesulfonate (PFOS), for 90 days. Hair, serum, and other tissues, including liver, kidney, spleen, lung, brain and heart, as well as the urine and feces excretions, were analyzed for PFAA levels. PFOA/PFNA/PFOS were detected in rat hair in a dose-dependent manner, in the order of PFOS > PFNA > PFOA. Hair PFAA concentrations were higher in male rats than the female rats, except for PFOS at low dose. Moreover, significant positive correlations as well as similar PFAA profiles were observed between hair, serum, and other tissues. Besides, hair PFAAs were negatively correlated with the urinary excretion rate. Although the influencing factors in humans still need further investigation, the results suggested that hair is capable of reflecting PFAA exposure, and could be employed as an alternative exposure bioindicator of PFAAs.
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