Hits:

Indexed by:Journal Papers

Date of Publication:2015-06-10

Journal:TETRAHEDRON

Included Journals:SCIE、Scopus

Volume:71

Issue:23

Page Number:3954-3959

ISSN No.:0040-4020

Key Words:Nano-palladium; Ligand-free; Suzuki-Miyaura reaction; Potassium aryltrifluoroborates; Room temperature

Abstract:A mild and simple protocol is described for the palladium-catalyzed ligand-free Suzuki-Miyaura reaction of potassium aryltrifluoroborates in aqueous ethanol at room temperature. Palladium nanoparticles are generated in situ in the reaction and demonstrate high activity towards a wide range of aryl bromides and potassium aryltrifluoroborates, providing biphenyls in good to excellent yields. Interestingly, only 1 equiv of K2CO3 is used in this catalytic system. Moreover, the key biaryl intermediate of 2-cyano-4'-methylbiphenyl within valsartan is prepared in a 95% yield after 2 h. (C) 2015 Elsevier Ltd. All rights reserved.