Release Time:2019-03-09  Hits:

Indexed by: Journal Papers

Date of Publication: 2015-06-10

Journal: TETRAHEDRON

Included Journals: Scopus、SCIE

Volume: 71

Issue: 23

Page Number: 3954-3959

ISSN: 0040-4020

Key Words: Nano-palladium; Ligand-free; Suzuki-Miyaura reaction; Potassium aryltrifluoroborates; Room temperature

Abstract: A mild and simple protocol is described for the palladium-catalyzed ligand-free Suzuki-Miyaura reaction of potassium aryltrifluoroborates in aqueous ethanol at room temperature. Palladium nanoparticles are generated in situ in the reaction and demonstrate high activity towards a wide range of aryl bromides and potassium aryltrifluoroborates, providing biphenyls in good to excellent yields. Interestingly, only 1 equiv of K2CO3 is used in this catalytic system. Moreover, the key biaryl intermediate of 2-cyano-4'-methylbiphenyl within valsartan is prepared in a 95% yield after 2 h. (C) 2015 Elsevier Ltd. All rights reserved.